Radiation-induced morphea refers to the development of morphea, a cutaneous fibrosing connective tissue disorder, in the setting of prior radiation therapy. It is predominantly reported in females. The most common location is the breast, due to history of breast cancer, although it has also been reported after radiation for head and neck cancer, gastric cancer, HIV-related lymphoma, endometrial cancer, cervical cancer, and adenocarcinoma of unknown origin. It is estimated that radiation-induced morphea occurs in up to 1% of patients. It typically occurs within 1 year of radiation, but it may occur up to 32 years after radiation. A history of autoimmune disease may increase the risk of developing radiation-induced morphea, whereas patient age, radiation dose, and treatment technique do not appear to significantly affect risk.