Plasma cell vulvitis, or Zoon disease, refers to an extremely rare skin condition where, secondary to inflammation, the vulva becomes irritated, leading to patient complaints of itching and discomfort.

The etiology is unknown but is thought to be related to viral elements, trauma, and/or chronic irritation. The condition tends to be diagnosed in postmenopausal patients.

Patients can present with long-standing complaints of mild itching, pain, burning, and/or bleeding of the vulva. Symptoms may coincide with intercourse. Often, patients report just that a specific area of the vulva is uncomfortable or annoying. Many patients will be asymptomatic and unaware of any issues.