Hypomelia-hypotrichosis-facial hemangioma syndrome (Roberts syndrome or Roberts-SC phocomelia syndrome) is a rare autosomal recessive genetic condition associated with high mortality. Caused by a defect on gene ESCO2. Characterized by pre- and postnatal growth retardation and significant intellectual disability, though cases with normal cognition have been reported. Craniofacial abnormalities may include microbrachycephaly, flat nose, cleft lip / palate, hypertelorism, sparse hair, proptosis, micrognathia, and facial hemangioma. All 4 limbs may be underdeveloped or absent. Abnormalities of the limbs include contracture, clinodactyly, syndactyly, club foot, and phocomelia. The genitourinary system is commonly found to have abnormal structures; rarely, renal and cardiac defects occur.

Treatment is based on the presence and severity of symptoms.