Bromoderma, the cutaneous manifestation of bromism (chronic bromide intoxication), is a form of halogenoderma that presents as acneiform papules and pustules, vegetative plaques, ulcers, or rarely bullae. It is a neutrophilic dermatosis that occurs in approximately 35% of patients with bromism. The earliest lesions tend to be more pustular, but this progresses to more papular and vegetative presentations in longstanding lesions.

Gastrointestinal (GI) symptoms of bromism include anorexia, weight loss, and nausea. Central nervous system (CNS) manifestations observed are ataxia and tremor along with confusion, delirium, or even full psychosis.

Bromoderma may develop more frequently in patients with renal impairment due to elongation of bromide half-life.

Bromine and bromides can be found in prescription medications (eg, ipratropium bromide) and over-the-counter (OTC) medications (eg, dextromethorphan hydrobromide). Rarely, brominated vegetable oil (BVO) is still used as an emulsifier in citrus-based soft drinks.