Limb-girdle muscular dystrophy (LGMD) encompasses a group of over 20 inherited disorders, all characterized by symmetric weakness of the proximal arms and legs. Most are autosomal recessive, but there are some autosomal dominant subtypes; spontaneous mutations also occur. Age of onset is typically in childhood or early adulthood, although the condition can present later in life. Symptoms include progressive weakness of the hips, pelvis, and shoulders, abnormal gait (often lordotic), frequent falls, and muscle atrophy. Depending on the mutation, there may be associated cardiomyopathy or contractures.

Prognosis varies considerably in both individuals and genetic subtype, with some patients progressing rapidly to death from respiratory compromise and other patients remaining ambulatory and having a normal lifespan.