Steroid atrophy presents as thinning of the skin and results from exposure to corticosteroids. Localized thinning occurs following the direct application of topical agents to the skin. Localized subcutaneous atrophy is one of the most common adverse effects of intramuscular corticosteroids. Atrophied skin may also be found over areas where intralesional steroids have been injected.

In an infant, steroid atrophy can be seen when diaper dermatitis is treated with potent topical steroids for long periods, and in rarer cases, may lead to Cushing syndrome.