Nevus depigmentosus (also known as nevus achromicus or achromic nevus) is a hypopigmented skin lesion that classically presents at birth. It is characterized by focal nonprogressive hypopigmentation that remains stable in shape and distribution throughout life, although its size typically grows in proportion to overall body growth. While nevus depigmentosus typically presents at birth or at a very early age, it may become more apparent later in childhood in infants with lighter skin colors. Nevus depigmentosus occurs sporadically, and there is no known inheritance pattern.

Nevus depigmentosus is not associated with systemic abnormalities, and lesions do not have malignant potential.